| Date | Home | Away | Result |
|---|---|---|---|
| 20/02/25 17:45 | Olimpija Ljubljana | FK Borac | 0-0 |
| 20/02/25 17:45 | Pafos FC | Omonia Nicosia | 2-1 |
| 20/02/25 17:45 | 1. FC Heidenheim 1846 | FC Copenhagen | 1-3a.e.t |
| 20/02/25 17:45 | Real Betis Sevilla | KAA Gent | 0-1 |
| 20/02/25 20:00 | Shamrock Rovers | Molde FK | 4-6a.PSO |
| 20/02/25 20:00 | Panathinaikos Athens | Vikingur Reykjavik | 2-0 |
| 20/02/25 20:00 | APOEL Nikosia | NK Celje | 0-2 |
| 20/02/25 20:00 | Jagiellonia Bialystok | TSC Backa Topola | 3-1 |