| Date | Home | Away | Result |
|---|---|---|---|
| 19/12/24 20:00 | Chelsea FC | Shamrock Rovers | 5-1 |
| 19/12/24 20:00 | Real Betis Sevilla | HJK Helsinki | 1-0 |
| 19/12/24 20:00 | Linzer ASK | Vikingur Reykjavik | 1-1 |
| 19/12/24 20:00 | Djurgardens IF | Legia Warschau | 3-1 |
| 19/12/24 20:00 | APOEL Nikosia | FK Astana | 1-1 |
| 19/12/24 20:00 | Molde FK | FK Mlada Boleslav | 4-3 |
| 19/12/24 20:00 | 1. FC Heidenheim 1846 | FC St.Gallen | 1-1 |
| 19/12/24 20:00 | Vitoria Guimaraes | Fiorentina | 1-1 |
| 19/12/24 20:00 | SK Rapid Wien | FC Copenhagen | 3-0 |
| 19/12/24 20:00 | KSV Cercle Brügge | Istanbul Basaksehir FK | 1-1 |
| 19/12/24 20:00 | Jagiellonia Bialystok | Olimpija Ljubljana | 0-0 |
| 19/12/24 20:00 | Larne FC | KAA Gent | 1-0 |
| 19/12/24 20:00 | Heart of Midlothian | FC Petrocub Hincesti | 2-2 |
| 19/12/24 20:00 | FC Lugano | Pafos FC | 2-2 |
| 19/12/24 20:00 | Panathinaikos Athens | Dinamo Minsk | 4-0 |
| 19/12/24 20:00 | TSC Backa Topola | FC Noah | 4-3 |
| 19/12/24 20:00 | FK Borac | Omonia Nicosia | 0-0 |
| 19/12/24 20:00 | NK Celje | The New Saints FC | 3-2 |